Welcome to the homepage of BIOGEM, at the University of California, San Diego.
The Biomedical Genomics laboratory (BIOGEM) is a genomics facility located in the Department of Medicine at UCSD. (BIOGEM) was established in 2000 to provide spotted cDNA microarray technology to the UCSD research community. Since then the scope has been expanded to include a variety of related services and resources, including several commercial microarray platforms and second (next-gen) and third generation sequencing technology. Currently BIOGEM provides RNA sample analysis and quantification services. Additionally BIOGEM processes commercial array platforms including Illumina and Agilent. Presently BIOGEM has 2 Illumina HiSeq2000 instruments and supports a variety of sequencing assays including DNA-sequencing, digital gene expression, small RNA sequencing, chIP-sequencing and bisulfite sequencing. BIOGEM offers Pacific Biosciences Single Molecule Real Time (SMRT) DNA sequencing technology. This new platfom enables, the observation of natural DNA synthesis by a DNA polymerase as it occurs. The approach is based on eavesdropping on a single DNA polymerase molecule working in a continuous, processive manner. Distinguished by long reads, fast time to results, more informative data, and lower overall costs, SMRT DNA sequencing promises to be a transformative technology that will enable a new paradigm in genomic analysis.
BIOGEM also provides image scanning and data analysis services.
Microarray and high-throughput sequencing experimentation, data acquisition and analysis require expensive instrumentation and reagents and a highly skilled team of individuals who are experts in specific components of the overall procedure. These technologies therefore lie beyond the scope of most individual laboratories and can only be made accessible to academic investigators through common core facilities. In addition to providing conventional genomic services, such cores provide essential platforms for advancing new technologies.
The Biomedical Genomics (BIOGEM) Core facility at UCSD has been instrumental in providing UCSD investigators access to these technologies. The facility has played a key role in enabling UCSD faculty to effectively compete for extramural grant support. The value of these technologies in discovery research has enabled investigators to identify signal transduction pathways, uncover new targets for therapeutic intervention, and reveal biomarkers for disease detection, prognosis, and guide treatment decision-making.
BIOGEM currently offers a range of genomics services from DNA microarray to HTS sequencing and data analysis services to regional and international academic and biotech communities. Please contact Dr. Gary Hardiman for more details.
Gary Hardiman Ph.D.
For more information on Dr. Hardiman's research and teaching activities please click here.
Last Updated November 2012
By Dr. Gary Hardiman